{"id":33,"date":"2023-01-24T10:48:03","date_gmt":"2023-01-24T01:48:03","guid":{"rendered":"https:\/\/www.eiiris.tut.ac.jp\/numano\/?page_id=33"},"modified":"2023-02-27T15:54:44","modified_gmt":"2023-02-27T06:54:44","slug":"publications-en","status":"publish","type":"page","link":"https:\/\/www.eiiris.tut.ac.jp\/numano\/publications-en\/","title":{"rendered":"Publications"},"content":{"rendered":"\n

Publications<\/h2>\n\n\n\n

Original papers<\/h3>\n\n\n\n

<\/p>\n\n\n\n

2022<\/strong><\/h4>\n\n\n\n
    \n
  1. The long nanowire DNA stamper transfers gene directly into brain cells ex vivo and in vivo.
    Numano R<\/u><\/strong><\/strong>, Goryu A, Kubota Y, Sawahata H, Yamagiwa S, Matsuo M, Iimura T, Tei H, Ishida M and Kawano T
    FEBS Open Bio.\u00a02022 Apr; 12(4): 835\u2013851.<\/li>\n\n\n\n
  2. Influence of Electroporation Medium on Delivery of Cell-Impermeable Small Molecules by Electrical Short-Circuiting via an Aqueous Droplet in Dielectric Oil: A Comparison of Different Fluorescent Tracers.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0
    Watanabe Y, Nihonyanagi H, Numano R<\/u><\/strong>, Shibata T, Takashima K, Kurita
    Sensors (Basel).\u00a02022 Mar 24;22(7):2494.<\/li>\n\n\n\n
  3. \u00a0A floating 5 \u03bcm-diameter needle electrode on the tissue for damage-reduced chronic neuronal recording in mice.
    Yamashita K, Sawahata H, Yamagiwa S, Yokoyama S, Numano R<\/u><\/strong>, Koida K,\u00a0 Kawano T.
    Lab on a Chip, Vol. 22, No. 4, pp. 747-756, 2022.<\/li>\n\n\n\n
  4. Nanoneedle-Electrode Devices for In Vivo Recording of Extracellular Action Potentials.
    Banno T, Tsuruhara S, Seikoba Y, Tonai R, Yamashita K, Idogawa S, Kita Y, Suzuki K, Yagi Y, Kondo Y, Numano R<\/u><\/strong>, Koida K, Kawano T.
    ACS Nano. 16(7):10692-10700 ,2022 Jul.<\/li>\n\n\n\n
  5. \u00a0Influence of Electroporation Medium on Delivery of Cell-Impermeable Small Molecules by Electrical Short-Circuiting via an Aqueous Droplet in Dielectric Oil: A Comparison of Different Fluorescent Tracers.
    Watanabe Y, Nihonyanagi H, Numano R<\/u><\/strong>, Shibata T, Takashima K, Kurita H.
    Sensors (Basel). 22(7):2494. 2022 Mar.<\/li>\n\n\n\n
  6. Nanoscale-tipped wire array injections transfer DNA directly into brain cells ex\u2009vivo and in\u2009vivo.
    Numano R<\/u><\/strong>, Goryu A, Kubota Y, Sawahata H, Yamagiwa S, Matsuo M, Iimura T, Tei H, Ishida M, Kawano T.
    FEBS Open Bio.12(4):835-851. 2022 Apr.<\/li>\n<\/ol>\n\n\n\n

    2121<\/strong><\/h4>\n\n\n\n
      \n
    1. Three-micrometer-diameter needle electrode with an amplifier for extracellular in vivo recordings.
      Kita Y, Tsuruhara S, Kubo H, Yamashita K, Seikoba Y, Idogawa S, Sawahata H, Yamagiwa S, Leong XLA, Numano R<\/u><\/strong>, Koida K, Kawano T.
      Proc Natl Acad Sci U S A.2021 Apr 20;118(16)
      <\/li>\n<\/ol>\n\n\n\n

      2020<\/strong><\/h4>\n\n\n\n
        \n
      1. Mechanistic studies of gene delivery into mammalian cells by electrical short-circuiting via an aqueous droplet in dielectric oil.
        Kurita H, Nihonyanagi H, Watanabe Y, Sugano K, Shinozaki R, Kishikawa K, Numano R<\/u><\/strong>, Takashima K. PLoS One. 2020 Dec 4;15(12):e0243361. doi: 10.1371\/journal.pone.0243361. eCollection 2020.<\/li>\n\n\n\n
      2. Introduction of a plasmid and a protein into bovine and swine cells by water-in-oil droplet electroporation.                         \u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000Ishino T, Kurita H, Kirisawa R, Shimamoto Y, Numano R<\/u><\/strong>, Kitamura H
        J. Vet. Med. Sci., 82(1),p14\u201322<\/li>\n<\/ol>\n\n\n\n

        2019<\/strong><\/h4>\n\n\n\n
          \n
        1. Overcoming a major obstacle to the practical application of regenerative medicine: Paving the way for the mass production of iPS Cells.
          Numano R<\/u><\/strong>
          TUT Research No.17, 2019\u5e745\u6708<\/li>\n\n\n\n
        2. A Magnetically Assembled High-Aspect-Ratio Needle Electrode for Recording Neuronal Activity.
          Yasui T, Yamagiwa S, Sawahata H, Idogawa S, Kubota Y, Kita Y, Yamashita K, Numano R<\/u><\/strong>, Koida K, Kawano T.
          Adv Healthc Mater.e1801081., 2019<\/li>\n\n\n\n
        3. Donut-Shaped Stretchable Kirigami: Enabling Electronics to Integrate with the Deformable Muscle.
          Morikawa Y, Yamagiwa S, Sawahata H, Numano R,<\/u><\/strong> Koida K, Kawano T.
          Adv Healthc Mater. 2019 Nov 7:e1900939. doi: 10.1002\/adhm.201900939. , 2019<\/li>\n\n\n\n
        4. Flexible parylene-thread bioprobe and the sewing method for in vivo neuronal recordings
          Yamashita K, Sawahata H, Yamagiwa S, Morikawa Y, Numano R<\/u><\/strong>, Koida K, Kawano T
          Sensors and Actuators B: Chemical 316,p127835-127835, 2019<\/li>\n\n\n\n
        5. Introduction of a plasmid and a protein into bovine and swine cells by water-in-oil droplet electroporation.
          Ishino T, Kurita H, Kirisawa R, Shimamoto Y, Numano R<\/u><\/strong>, Kitamura H
          The Journal of veterinary medical science 82(1),p14-22,<\/li>\n\n\n\n
        6. Flow cytometric study on mechanism of gene delivery into mammalian cells by electrostatic actuation of a water droplet in dielectric oil                 \u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000Kurita H, Sugano K, Kishikawa K, Numano R<\/u><\/strong>, Takashima K\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u30003rd World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine, and Food & Environmental Technologies<\/li>\n\n\n\n
        7. Experimental and Computational Study on Efficient Intracellular Delivery Through Microdroplet-Based Electroporation\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000Ishii-Teshima M, Kurita H, Numano R<\/u><\/strong>, Nagai M, Shibata T\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000The 8th International Conference of Asian Society for Precision Engineering and Nanotechnology (ASPEN 2019)<\/li>\n\n\n\n
        8. Three Dimensional Core-Shell Microneedle-Electrode for Multisite Neuronal Recoding\u3000\u3000\u3000\u3000Idogawa S, Kubota Y, Yamagiwa S, Sawahata H, Numano R<\/u><\/strong>, Koida K, Kawano T\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u300020th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII)<\/li>\n\n\n\n
        9. A High-Density Array of 3D Microneedle-Electrodes for Evaluation of Spatial Resolution of Neuronal Activity\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000Kotani Y, Sawahata H, Yamagiwa S, Numano R<\/strong>, Koida K, Kawano T\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u300020th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII)<\/li>\n\n\n\n
        10. Floating 5-\u03bcm-Diameter Needle for Low Invasive Chronic Recording\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000Yamashita K, Sawahata H, Yamagiwa S, Numano R<\/u><\/strong>, Koida K, Kawano T\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u300020th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII)<\/li>\n\n\n\n
        11. Sewing Bioprobe\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000Yamashita K, Sawahata H, Yamagiwa S, Morikawa Y, Numano R<\/u><\/strong>, Koida K, Kawano T\u3000\u3000\u3000\u3000\u3000\u3000\u3000IEEE 32nd International Conference on Micro Electro Mechanical Systems (MEMS) ,p621-624<\/li>\n<\/ol>\n\n\n\n

          2018<\/strong><\/h4>\n\n\n\n
            \n
          1. \u5e79\u7d30\u80de\u7814\u7a76\u306e\u6700\u524d\u7dda\u301c\u57fa\u790e\u304b\u3089\u81e8\u5e8a\u307e\u3067\u301c \u6db2\u6ef4\u96fb\u6c17\u7a7f\u5b54\u88c5\u7f6e\u306e\u958b\u767a\u3068\u5e79\u7d30\u80de\u7814\u7a76\u3078\u306e\u5fdc\u7528
            \u6cbc\u91ce\u3000\u5229\u4f73<\/u><\/strong>, \u7be0\u5d0e \u7adc\u767b, \u677e\u5c3e \u7f8e\u5948\u5b50, \u6817\u7530 \u5f18\u53f2, \u677e\u672c \u5149\u4e8c\u6717, \u8d64\u677e \u548c\u58eb
            Cytometry Research 28(Suppl.) 29-29 2018\u5e745\u6708<\/li>\n\n\n\n
          2. A central-acting connexin inhibitor, INI-0602, prevents high-fat diet-induced feeding pattern disturbances and obesity in mice.
            Sasaki T, Numano R<\/u><\/strong>, Yokota-Hashimoto H, Matsui S, Kimura N, Takeuchi H, Kitamura T.
            Mol Brain, 11,p11-28, 2018<\/li>\n\n\n\n
          3. Ultrastretchable Kirigami Bioprobes. 
            Morikawa Y, Yamagiwa S, Sawahata H, Numano R<\/u><\/strong>, Koida K, Ishida M, Kawano T
            Adv Healthc Mater., 7(3) , 2018<\/li>\n\n\n\n
          4. Fiber bundle endomicroscopy with multi-illumination for three-dimensional reflectance image reconstruction     
            Ando Y, Sawahata H, Kawano T, Koida K, Numano R<\/u><\/strong>
            J Biomed Opt,3(2),p1-4. , 2018<\/li>\n\n\n\n
          5. Long nanoneedle-electrode devices for extracellular and intracellular recording in vivo.             
            Kubota Y, Yamagiwa S, Sawahata H, Idogawa S, Tsuruhara S, Numano R,<\/u><\/strong> Koida K, Ishida M, Kawano T
            Sensors and Actuators B: Chemical, 258, p1287-1294, 2018<\/li>\n\n\n\n
          6. Development of microdroplet-based electroporation system for gene transfection\u3000\u3000\u3000\u3000\u3000\u3000\u3000Ishii-Teshima M, Ushiroda F, Nagai M, Numano R<\/u><\/strong>, Shibata T\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000The 44th International Conference on Micro and Nano Engineering 2018 (MNE 2018)<\/li>\n\n\n\n
          7. Long nanowire array for in vivo in vitro DNA injections into cells in brain tissues   \u3000\u3000\u3000\u3000\u3000\u3000Kubota Y, Numano R<\/u><\/strong>, Goryu A, Sawahata H, Yamagiwa S, Matsuo M, Ishida M, Kawano T\u3000\u3000\u3000\u3000\u3000The 31th IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2018)<\/li>\n\n\n\n
          8. Dissolvable material-sheathed microneedle-electrode device slid into a narrow gap of the brain\u3000Yamagiwa S, Sawahata H, Numano R<\/u><\/strong>, Ishida M, Koida K, Kawano T\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000The 31th IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2018)<\/li>\n\n\n\n
          9. Stretchable micro-doughnuts Kirigami Bioporobe         \u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000Morikawa Y, Yamagiwa S, Sawahata H, Numano R<\/u><\/strong>, Koida K, Ishida M, Kawano T\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000The 31th IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2018)<\/li>\n\n\n\n
          10. Single needle electrode\u2013topped amplifier package (STACK) for in vivo applications\u3000\u3000\u3000\u3000\u3000\u3000\u3000Kita Y, Kubo H, Sawahata H, Yamagiwa S, X.L.A. Leong, Numano R<\/u><\/strong>, Koida K, Ishida M, Kawano T \u3000The 31th IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2018)<\/li>\n<\/ol>\n\n\n\n

            2017<\/strong><\/h4>\n\n\n\n
              \n
            1. Bone Resorption Is Regulated by Circadian Clock in Osteoblasts.
              Takarada T, Xu C, Ochi H, Nakazato R, Yamada D, Nakamura S, Kodama A, Shimba S, Mieda M, Fukasawa K, Ozaki K, Iezaki T, Fujikawa K, Yoneda Y, Numano R<\/u><\/strong>, Hida A, Tei H, Takeda S, Hinoi EJ,
              Journal Of Bone And Mineral Research,32, p872-881, 2017<\/li>\n\n\n\n
            2. The intrinsic microglial clock system regulates interleukin-6 expression.
              Nakazato R, Hotta S, Yamada D, Kou M, Nakamura S, Takahata Y, Tei H, Numano R<\/u><\/strong>, Hida A, Shimba S, Mieda M, Hinoi E, Yoneda Y, Takarada T.
              Glia 2017,65(1):198-208<\/li>\n\n\n\n
            3. Ultra high-aspect-ratio neuroprobe: 5-\u03bcm-diameter and 400-\u03bcm-length needle detects action potentials in VIVO\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000Yamagiwa S, Sawahata H, Oi H, Numano R<\/u><\/strong>, Ishida M, Koida K, Kawano T\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000IEEE 30th International Conference on Micro Electro Mechanical Systems (MEMS)\u3000,p553 – 556  <\/li>\n\n\n\n
            4. In vivo neuronal recordings using three-dimensional microneedle-electrode assembled on flexible substrate \u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000Yamagiwa S, Sawahata H, Numano R<\/u><\/strong>, Ishida M, Koida K, Kawano T\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000IEEE 30th International Conference on Micro Electro Mechanical Systems (MEMS) ,p1722 – 1725<\/li>\n\n\n\n
            5. In  transfection methodology for mammalian cells using water-in-oil droplet deformation in a DC electric field\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000Kurita H, Kishikawa K, Takao Y, Numano R<\/u><\/strong>, Takashima K, Mizuno A\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000The 2nd World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine, and Food & Environmental Technologies<\/li>\n<\/ol>\n\n\n\n

              2016<\/h4>\n\n\n\n
                \n
              1. Fundamental study on agenetransfection methodology for mammalian cellsusingwater-in-oildropletdeformationinaDC electric field
                Kurita H, Takao;Y,, Kishikawa K, Takashima K, Numano R<\/span><\/strong>, Mizuno A.
                Biochemistry andBiophysicsReports,\u67fb\u8aad\u6709,2016,8,p81\u201388<\/li>\n\n\n\n
              2. In vivo bioluminescence and reflectance imaging of multiple organs in bioluminescence reporter mice by bundled-fiber-coupled microscopy,
                Ando Y, Sakurai T, Koida K, Tei H, Hida A, Nakao K, Natsume M, Numano R<\/span><\/strong>
                Biomed.Opt.Express,\u67fb\u8aad\u6709,2016,7(3),p963-978<\/li>\n\n\n\n
              3. Reflectance Imaging by Fiber Bundle Endoscope: Vertical Reconstruction by Multipositional Illumination
                Ando Y, Koida K, Sawahata H, Sakurai T, Natsume M, Kawano T, and Numano R<\/span><\/strong>,
                AIP proceedings,\u67fb\u8aad\u6709,2016<\/li>\n\n\n\n
              4. Nanoscale-Tipped High-Aspect-Ratio Vertical Microneedle Electrodes for Intracellular Recordings
                Kubota Y, Oi H, Sawahata H, Goryu A, Ando Y, Numano R<\/span><\/strong>, Ishida M, Kawano T..
                Small,\u67fb\u8aad\u6709,2016,12(21):2846-53<\/li>\n\n\n\n
              5. Intracellular Electrodes: Nanoscale-Tipped High-Aspect-Ratio Vertical Microneedle Electrodes for Intracellular Recordings
                Kubota Y,Oi H, Sawahata H,\u3000Goryu A,Ando Y, Numano R<\/u><\/strong>, Ishida M, Kawano T
                Small,12(21), p2803\u20132931, 2016<\/li>\n\n\n\n
              6. Single 5\u2009\u03bcm diameter needle electrode block modules for unit recordings in vivo.  
                Sawahata H, Yamagiwa S, Moriya A, Dong T, Oi H, Ando Y, Numano R<\/u><\/strong>, Ishida M, Koida K, Kawano T.
                Scientific Reports,2016,25;6:35806<\/li>\n\n\n\n
              7. \u7d30\u80de\u3078\u306e\u907a\u4f1d\u5b50\u5c0e\u5165\u306e\u9769\u65b0\u7684\u65b0\u6cd5
                \u300c\u6b21\u4e16\u4ee3\u578b\u6db2\u6ef4\u30a8\u30ec\u30af\u30c8\u30ed\u30dd\u30ec\u30fc\u30b7\u30e7\u30f3\u300d\u306e\u958b\u767a
                – iPS\u7d30\u80de\u306e\u5927\u91cf\u88fd\u9020\u306a\u3069\u533b\u7642\u5fdc\u7528\u306b\u3080\u3051\u305f\u3082\u306e\u3064\u304f\u308a\u6280\u8853 –
                \u6cbc\u91ce\u3000\u5229\u4f73<\/u><\/strong>
                \u30af\u30ea\u30fc\u30f3\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u3001\u65e5\u672c\u5de5\u696d\u51fa\u7248 201\uff16\u5e74\uff11\uff11\u6708\u53f7\u3000<\/li>\n<\/ol>\n\n\n\n

                2015<\/h4>\n\n\n\n
                  \n
                1. Novel parallelized electroporation by electrostatic manipulation of a water-in-oil droplet as a microreactor, e0144254 (15pp), 2015
                  Kurita H, Takahashi S, Asada A, Matsuo M, Kishikawa K, Mizuno A, Numano R<\/span><\/strong>
                  PLoS One,2015,10(12)<\/li>\n\n\n\n
                2. Dissolvable Base Scaffolds Allow Tissue Penetration of High-Aspect-Ratio Flexible Microneedles
                  Yagi S, Yamagiwa S, Kubota Y, Sawahata H, Numano R<\/span><\/strong>, Imashioya T, Oi H, Ishida M, Kawano T.
                  Adv Healthc Mater. ,2015,in press<\/li>\n\n\n\n
                3. Low glucose-induced ghrelin secretion is mediated by ATP-sensitive potassium channe
                  Manami Oya1, Tetsuya Kitaguchi2,3, Kazuki Harada1, Rika Numano<\/span><\/strong>4,
                  Takahiro Sato5, Masayasu Kojima5, Takashi Tsubo
                  Journal of Endocrinology,2015,226(25-34).<\/li>\n\n\n\n
                4. Layer-by-layer assembled nanorough iridium-oxide\/platinum-black for low-voltage microscale electrode neurostimulation
                  Shota Yamagiwaa, Akifumi Fujishiroa, Hirohito Sawahataa, Rika Numano<\/span><\/strong>b,c,Makoto Ishidaa,b, Takeshi Kawanoa,\u2217<\/sup>
                  Sensors and Actuators B: Chemical ,2015,206(205\u2013211)<\/li>\n<\/ol>\n\n\n\n

                  2014<\/h4>\n\n\n\n
                    \n
                  1. Short hairpin RNAs of designed sequences can be extracellularly produced by the marine bacterium Rhodovulum sulfidophilum
                    Nagao N, Suzuki H, Numano R<\/span><\/strong>, Umekage S, Kikuchi Y
                    J Gen Appl Microbiol. ,2014,60\uff08222\uff5e 226\uff09<\/li>\n\n\n\n
                  2. Melanopsin resets circadian rhythms in cells by inducing clock genePeriod
                    Shuhei Yamashita, Tomoe Uehara, Minako Matsuo, Yo Kikuchi and Rika Numano<\/span><\/strong>
                    AIP Conf. Proc. ,2014,1585, 40-44<\/li>\n\n\n\n
                  3. A vertically integrated nanoscale tipped microprobe intracellular electrode arra
                    Kubota, Y. ,Oi, H. , Sawahata, H. , Goryu, A., Ando, Y., Numano R<\/span><\/strong>, Ishida, M. , Kawano,
                    Micro Electro Mechanical Systems (MEMS) ,2014,155 \u2013 158<\/li>\n<\/ol>\n\n\n\n

                    2013<\/h4>\n\n\n\n
                      \n
                    1. Vesicular nucleotide transporter is involved in ATP storage of secretory lysosomes in astrocyte
                      Oya M, Kitaguchib T, Yanagihara Y, Numano R<\/span><\/strong>, Kakeyama M, Ikematsu K, Tsuboi
                      Biochem Biophys Res Commun ,2013,16(145\uff5e151\uff09<\/li>\n<\/ol>\n\n\n\n

                      2012<\/h4>\n\n\n\n
                        \n
                      1. Small GTPase Cdc42 modulates the number of exocytosis-competent dense-core vesicles in PC12 cells.
                        Sato M, Kitaguchi T, Numano R<\/span><\/strong>, Ikematsu K, Kakeyama M, Murata M, Sato K, Tsuboi T
                        Biochem Biophys Res Commun ,2012,30(254-269\uff09<\/li>\n\n\n\n
                      2. Nanoscale tipped microwire arrays enhance electrical trap and depth injection of nanoparticles
                        Goryu A, Numano R<\/span><\/strong>, Ikedo A, Ishida M, Kawano T
                        Nanotechnology. ,2012,23\uff082741\uff5e 2705\uff09<\/li>\n\n\n\n
                      3. A fluorescence spotlight on the clockwork development and metabolism of bone
                        Tadahiro Iimura* , Ayako Nakane, Mayu Sugiyama, Hiroki Sato, Yuji Makino, Takashi Watanabe, Yuzo Takagi, Rika Numano<\/span><\/strong>*, Akira Yamaguchi
                        J Bone Miner Metab ,2012,24\uff0855\uff5e 63\uff09<\/li>\n<\/ol>\n\n\n\n

                        2011<\/h4>\n\n\n\n
                          \n
                        1. \u9aa8\u306e\u6210\u9577\u3068\u4ee3\u8b1d\u306b\u304a\u3051\u308b\u6982\u65e5\u30ea\u30ba\u30e0\u306e\u50cd\u304d \uff0d\u86cd\u5149\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306b\u3088\u308b\u30a2\u30d7\u30ed\u30fc\u30c1\u3068\u5c55\u671b\uff0d
                          Ayako Nakane, Rika Numano<\/span><\/strong>* ,Yuzo Takagi , Akira Yamaguchi, Tadahiro Iimura
                          Jounal of Bone morphometry,2011,21\uff0841-50\uff09<\/li>\n\n\n\n
                        2. \u53cc\u65b9\u5411\u306e\u5149\u53cd\u5fdc\u6027\u3092\u6301\u3064Yin\/Yang\u53d7\u5bb9\u4f53
                          \u7d30\u80de\u5de5\u5b66\u3001\u7f8a\u571f\u793e 2011\u5e748\u6708\u53f7\u3000\u5e73\u621023\u5e74
                          \u6cbc\u91ce\u3000\u5229\u4f73<\/u><\/strong><\/li>\n\n\n\n
                        3. Fluorescent imaging approach and perspective for the circadian development and metabolism of bone
                          Jounal of Bone morphometry. Vol.21, p41-50, 2011
                          Nakane A, Numano R*<\/u><\/strong>, Takagi Y, Yamaguchi A, Iimura T<\/li>\n<\/ol>\n\n\n\n

                          2009<\/h4>\n\n\n\n
                            \n
                          1. Nanosculpting reversed wavelength sensitivity into a photoswitchable iGluR.
                            Numano R<\/span><\/strong>, Szobota S, Lau AY, Gorostiza P, Volgraf M, Roux B, Trauner D, Isacoff EY
                            Proc Natl Acad Sci U S A,106, 2009,p6814-6819<\/li>\n\n\n\n
                          2. Ontogeny of circadian organization in the rat.
                            Yamazaki S, Yoshikawa T, Biscoe EW, Numano R<\/span><\/strong>, Gallaspy LM, Soulsby S, Papadimas E, Pezuk P, Doyle SE, Tei H, Sakaki Y, Block GD, Menaker M\uff0a<\/sup>.
                            J Biol Rhythms., 24, 2009,\u3000p55-63<\/li>\n<\/ol>\n\n\n\n

                            2007<\/h4>\n\n\n\n
                              \n
                            1. Remote control of neuronal activity with a light-gated glutamate receptor.
                              Szobota S, Gorostiza P, Del Bene F, Wyart C, Fortin DL, Kolstad KD, Tulyathan O, Volgraf M, Numano R<\/span><\/strong>, Aaron HL, Scott EK, Kramer RH, Flannery J, Baier H, Trauner D, Isacoff EY.
                              Neuron, 54, 2007, p535-545<\/li>\n\n\n\n
                            2. Mechanisms of photoswitch conjugation and light activation of an ionotropic glutamate receptor.
                              Gorostiza P, Volgraf M, Numano R<\/span><\/strong>, Szobota S, Trauner D, Isacoff EY.
                              Proc Natl Acad Sci U S A, 104, 2007,p10865-10870<\/li>\n\n\n\n
                            3. Remote control of neuronal activity with a light-gated glutamate receptor.
                              Szobota S, Gorostiza P, Del Bene F, Wyart C, Fortin DL, Kolstad KD, Tulyathan O, Volgraf M, Numano R<\/span><\/strong>, Aaron HL, Scott EK, Kramer RH, Flannery J, Baier H, Trauner D, Isacoff EY\uff0a.
                              Neuron, 54, 2007, p535-545<\/li>\n<\/ol>\n\n\n\n

                              2006<\/h4>\n\n\n\n
                                \n
                              1. Constitutive expression of the Period1 gene impairs behavioral and molecular circadian rhythms.
                                Numano R<\/span><\/strong>, Yamazaki S, Umeda N, Samura T, Sujino M, Takahashi R, Ueda M, Mori A, Yamada K, Sakaki Y, Inouye ST, Menaker M, Tei H.
                                Proc Natl Acad Sci U S A, 103,p3716-3721, 2006<\/li>\n\n\n\n
                              2. Allosteric control of an ionotropic glutamate receptor with an optical switch.
                                Volgraf M, Gorostiza P, Numano R<\/span><\/strong>, Kramer RH, Isacoff EY, Trauner D.
                                Nat Chem Biol., 2, p47-52, 2006<\/li>\n<\/ol>\n\n\n\n

                                2004<\/h4>\n\n\n\n
                                  \n
                                1. Temporal precision in the mammalian circadian system: a reliable clock from less reliable neurons.
                                  Herzog ED, Aton SJ, Numano R<\/span><\/strong>, Sakaki Y, Tei H.
                                  J Biol Rhythms.,19,p35-46, 2004<\/li>\n<\/ol>\n\n\n\n

                                  2002<\/h4>\n\n\n\n
                                    \n
                                  1. Transgenic rats in study of mammalian circadian rhythms.
                                    Numano R<\/span><\/strong>
                                    Anitex, 14, p203-209, 2002<\/li>\n<\/ol>\n\n\n\n

                                    2001<\/h4>\n\n\n\n
                                      \n
                                    1. The coupling of central and peripheral circadian oscillators in the mammalian circadian system by means of Period1 expression profile
                                      Numano R<\/span><\/strong>, Tei H
                                      Shinkei Kenkyu no Shinpo, 45, p734-743, 2001<\/li>\n\n\n\n
                                    2. The coupling of central and peripheral circadian oscillators in the mammalian circadian system by means of Period1 expression profile
                                      Shinkei Kenkyu no Shinpo, 45\u5dfb\uff08734\u9801\uff5e743\u9801\uff09\u5e73\u621013\u5e74
                                      Numano R<\/span><\/strong>, Tei H<\/li>\n<\/ol>\n\n\n\n

                                      2000<\/h4>\n\n\n\n
                                        \n
                                      1. Resetting central and peripheral circadian oscillators in transgenic rats.
                                        *Yamazaki S, *Numano R<\/span><\/strong>, *Abe M, Hida A, Takahashi R, Ueda M, Block GD, Sakaki Y, Menaker M, Tei H.
                                        Science, \u67fb\u8aad\u6709,288,p682-685, 2000\u3000\u3000*equally contributed<\/li>\n<\/ol>\n\n\n\n

                                        1998<\/h4>\n\n\n\n
                                          \n
                                        1. 2,2′-Azobis (4-methoxy-2,4-dimethylvaleronitrile), a new lipid-soluble azo initiator: application to oxidations of lipids and low-density lipoprotein in solution and in aqueous dispersions.
                                          Noguchi N, Yamashita H, Gotoh N, Yamamoto Y, Numano R<\/span><\/strong>, Niki E.
                                          Free Radic Biol Med., 24, p259-268, 1998<\/li>\n\n\n\n
                                        2. Oxidation of lipids in low density lipoprotein particles.
                                          Noguchi N, Numano R<\/span><\/strong>, Kaneda H, Niki E.
                                          Free Radic Res., 29, p43-52, 1998<\/li>\n\n\n\n
                                        3. Identification of the mammalian homologues of the Drosophila timeless gene, Timeless1.
                                          Koike N, Hida A, Numano R<\/span><\/strong>, Hirose M, Sakaki Y, Tei H.
                                          FEBS Lett., 441,p427-431, 1998<\/li>\n\n\n\n
                                        4. Human clock controlled gene, Period1
                                          Numano R<\/span><\/strong> , Tei H , Sakaki Y
                                          Medical Technology, 26, p213-215, 1998<\/li>\n<\/ol>\n\n\n\n

                                          <\/p>\n","protected":false},"excerpt":{"rendered":"

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