{"id":19,"date":"2023-01-24T10:45:03","date_gmt":"2023-01-24T01:45:03","guid":{"rendered":"https:\/\/www.eiiris.tut.ac.jp\/numano\/?page_id=19"},"modified":"2023-02-27T15:43:18","modified_gmt":"2023-02-27T06:43:18","slug":"publications","status":"publish","type":"page","link":"https:\/\/www.eiiris.tut.ac.jp\/numano\/publications\/","title":{"rendered":"\u7814\u7a76\u696d\u7e3e"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u696d\u7e3e<\/h2>\n\n\n\n<ul class=\"icon wp-block-list\">\n<li><a href=\"#1\" data-type=\"internal\" data-id=\"#1\">\u8ad6\u6587<\/a><\/li>\n\n\n\n<li><a href=\"#2\" data-type=\"internal\" data-id=\"#2\">\u51fa\u7248\u56f3\u66f8<\/a><\/li>\n\n\n\n<li><a href=\"#3\" data-type=\"internal\" data-id=\"#3\">\u7814\u7a76\u52a9\u6210<\/a><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"1\">\u8ad6\u6587<\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2022<\/strong><\/h4>\n\n\n\n<ol class=\"wp-block-list\">\n<li>The long nanowire DNA stamper transfers gene directly into brain cells ex vivo and in vivo.<br><strong><span style=\"text-decoration: underline;\">Numano R<\/span><\/strong>, Goryu A, Kubota Y, Sawahata H, Yamagiwa S, Matsuo M, Iimura T, Tei H, Ishida M and Kawano T<br>FEBS Open Bio.&nbsp;2022 Apr; 12(4): 835\u2013851.<\/li>\n\n\n\n<li>Influence of Electroporation Medium on Delivery of Cell-Impermeable Small Molecules by Electrical Short-Circuiting via an Aqueous Droplet in Dielectric Oil: A Comparison of Different Fluorescent Tracers.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<br>Watanabe Y, Nihonyanagi H, <strong><span style=\"text-decoration: underline;\">Numano R<\/span><\/strong>, Shibata T, Takashima K, Kurita<br>Sensors (Basel).&nbsp;2022 Mar 24;22(7):2494.<\/li>\n\n\n\n<li>&nbsp;A floating 5 \u03bcm-diameter needle electrode on the tissue for damage-reduced chronic neuronal recording in mice.<br>Yamashita K, Sawahata H, Yamagiwa S, Yokoyama S, <strong><span style=\"text-decoration: underline;\">Numano R<\/span><\/strong>, Koida K,&nbsp; Kawano T.<br>Lab on a Chip, Vol. 22, No. 4, pp. 747-756, 2022.<\/li>\n\n\n\n<li>Nanoneedle-Electrode Devices for In Vivo Recording of Extracellular Action Potentials.<br>Banno T, Tsuruhara S, Seikoba Y, Tonai R, Yamashita K, Idogawa S, Kita Y, Suzuki K, Yagi Y, Kondo Y, <strong><span style=\"text-decoration: underline;\">Numano R<\/span><\/strong>, Koida K, Kawano T.<br>ACS Nano. 16(7):10692-10700 ,2022 Jul.<\/li>\n\n\n\n<li>&nbsp;Influence of Electroporation Medium on Delivery of Cell-Impermeable Small Molecules by Electrical Short-Circuiting via an Aqueous Droplet in Dielectric Oil: A Comparison of Different Fluorescent Tracers.<br>Watanabe Y, Nihonyanagi H, <strong><span style=\"text-decoration: underline;\">Numano R<\/span><\/strong>, Shibata T, Takashima K, Kurita H.<br>Sensors (Basel). 22(7):2494. 2022 Mar.<\/li>\n\n\n\n<li>Nanoscale-tipped wire array injections transfer DNA directly into brain cells ex\u2009vivo and in\u2009vivo.<br><strong><span style=\"text-decoration: underline;\">Numano R<\/span><\/strong>, Goryu A, Kubota Y, Sawahata H, Yamagiwa S, Matsuo M, Iimura T, Tei H, Ishida M, Kawano T.<br>FEBS Open Bio.12(4):835-851. 2022 Apr.<\/li>\n<\/ol>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2021<\/strong><\/h4>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Three-micrometer-diameter needle electrode with an amplifier for extracellular in vivo recordings.<br>Kita Y, Tsuruhara S, Kubo H, Yamashita K, Seikoba Y, Idogawa S, Sawahata H, Yamagiwa S, Leong            XLA, <strong><u>Numano R<\/u><\/strong>, Koida K, Kawano T.<br>Proc Natl Acad Sci U S A.2021 Apr 20;118(16)<\/li>\n<\/ol>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2020<\/strong><\/h4>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Mechanistic studies of gene delivery into mammalian cells by electrical short-circuiting via an aqueous droplet in dielectric oil.<br>Kurita H, Nihonyanagi H, Watanabe Y, Sugano K, Shinozaki R, Kishikawa K, <strong><u>Numano R<\/u><\/strong>, Takashima K. PLoS One. 2020 Dec 4;15(12):e0243361. doi: 10.1371\/journal.pone.0243361. eCollection 2020.<\/li>\n\n\n\n<li>Introduction of a plasmid and a protein into bovine and swine cells by water-in-oil droplet electroporation\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000Ishino T, Kurita H, Kirisawa R, Shimamoto Y, <strong><u>Numano R<\/u><\/strong>, Kitamura H <br>J. Vet. Med. Sci., 82(1),p14\u201322<\/li>\n<\/ol>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2019<\/strong><\/h4>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Overcoming a major obstacle to the practical application of regenerative medicine: Paving the way for the mass production of iPS Cells.<br><strong><u>\u6cbc\u91ce\u3000\u5229\u4f73<\/u><\/strong><br>TUT Research No.17, 2019\u5e745\u6708<\/li>\n\n\n\n<li>A Magnetically Assembled High-Aspect-Ratio Needle Electrode for Recording Neuronal Activity.<br>Yasui T, Yamagiwa S, Sawahata H, Idogawa S, Kubota Y, Kita Y, Yamashita K, <strong><u>Numano R<\/u><\/strong>, Koida K, Kawano T.<br>Adv Healthc Mater.e1801081., 2019<\/li>\n\n\n\n<li>Donut-Shaped Stretchable Kirigami: Enabling Electronics to Integrate with the Deformable Muscle.<br>Morikawa Y, Yamagiwa S, Sawahata H, <strong><u>Numano R,<\/u><\/strong> Koida K, Kawano T.<br>Adv Healthc Mater. 2019 Nov 7:e1900939. doi: 10.1002\/adhm.201900939. , 2019<\/li>\n\n\n\n<li>Flexible parylene-thread bioprobe and the sewing method for in vivo neuronal recordings<br>Yamashita K, Sawahata H, Yamagiwa S, Morikawa Y, <strong><u>Numano R<\/u><\/strong>, Koida K, Kawano T<br>Sensors and Actuators B: Chemical 316,p127835-127835, 2019<\/li>\n\n\n\n<li>Introduction of a plasmid and a protein into bovine and swine cells by water-in-oil droplet electroporation.<br>Ishino T, Kurita H, Kirisawa R, Shimamoto Y, <strong><u>Numano R<\/u><\/strong>, Kitamura H<br>The Journal of veterinary medical science 82(1),p14-22<\/li>\n\n\n\n<li>Flow cytometric study on mechanism of gene delivery into mammalian cells by electrostatic actuation of a water droplet in dielectric oil&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000Kurita H, Sugano K, Kishikawa K, <strong><u>Numano R<\/u><\/strong>, Takashima K\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u30003rd World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine, and Food &amp; Environmental Technologies<\/li>\n\n\n\n<li>Experimental and Computational Study on Efficient Intracellular Delivery Through Microdroplet-Based Electroporation\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000Ishii-Teshima M, Kurita H, <strong><u>Numano R<\/u><\/strong>, Nagai M, Shibata T\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000The 8th International Conference of Asian Society for Precision Engineering and Nanotechnology (ASPEN 2019)<\/li>\n\n\n\n<li>Three Dimensional Core-Shell Microneedle-Electrode for Multisite Neuronal Recoding\u3000\u3000\u3000\u3000Idogawa S, Kubota Y, Yamagiwa S, Sawahata H, <strong><u>Numano R<\/u><\/strong>, Koida K, Kawano T\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u300020th International Conference on Solid-State Sensors, Actuators and Microsystems &amp; Eurosensors XXXIII (TRANSDUCERS &amp; EUROSENSORS XXXIII)<\/li>\n\n\n\n<li>A High-Density Array of 3D Microneedle-Electrodes for Evaluation of Spatial Resolution of Neuronal Activity\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000Kotani Y, Sawahata H, Yamagiwa S, <strong>Numano R<\/strong>, Koida K, Kawano T\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u300020th International Conference on Solid-State Sensors, Actuators and Microsystems &amp; Eurosensors XXXIII (TRANSDUCERS &amp; EUROSENSORS XXXIII)<\/li>\n\n\n\n<li>Floating 5-\u03bcm-Diameter Needle for Low Invasive Chronic Recording\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000Yamashita K, Sawahata H, Yamagiwa S, <strong><u>Numano R<\/u><\/strong>, Koida K, Kawano T\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u300020th International Conference on Solid-State Sensors, Actuators and Microsystems &amp; Eurosensors XXXIII (TRANSDUCERS &amp; EUROSENSORS XXXIII)<\/li>\n\n\n\n<li>Sewing Bioprobe\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000Yamashita K, Sawahata H, Yamagiwa S, Morikawa Y, <strong><u>Numano R<\/u><\/strong>, Koida K, Kawano T\u3000\u3000\u3000\u3000\u3000\u3000\u3000IEEE 32nd International Conference on Micro Electro Mechanical Systems (MEMS) ,p621-624<\/li>\n<\/ol>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2018<\/strong><\/h4>\n\n\n\n<ol class=\"wp-block-list\">\n<li>\u5e79\u7d30\u80de\u7814\u7a76\u306e\u6700\u524d\u7dda\u301c\u57fa\u790e\u304b\u3089\u81e8\u5e8a\u307e\u3067\u301c \u6db2\u6ef4\u96fb\u6c17\u7a7f\u5b54\u88c5\u7f6e\u306e\u958b\u767a\u3068\u5e79\u7d30\u80de\u7814\u7a76\u3078\u306e\u5fdc\u7528<br><strong><u>\u6cbc\u91ce\u3000\u5229\u4f73<\/u><\/strong>, \u7be0\u5d0e \u7adc\u767b, \u677e\u5c3e \u7f8e\u5948\u5b50, \u6817\u7530 \u5f18\u53f2, \u677e\u672c \u5149\u4e8c\u6717, \u8d64\u677e \u548c\u58eb<br>Cytometry Research 28(Suppl.) 29-29 2018\u5e745\u6708<\/li>\n\n\n\n<li>A central-acting connexin inhibitor, INI-0602, prevents high-fat diet-induced feeding pattern disturbances and obesity in mice.<br>Sasaki T, <strong><u>Numano R<\/u><\/strong>, Yokota-Hashimoto H, Matsui S, Kimura N, Takeuchi H, Kitamura T.<br>Mol Brain, 11,p11-28, 2018<\/li>\n\n\n\n<li>Ultrastretchable Kirigami Bioprobes.&nbsp; <br>Morikawa Y, Yamagiwa S, Sawahata H, <strong><u>Numano R<\/u><\/strong>, Koida K, Ishida M, Kawano T<br>Adv Healthc Mater., 7(3) , 2018<\/li>\n\n\n\n<li>Fiber bundle endomicroscopy with multi-illumination for three-dimensional reflectance image reconstruction&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<br>Ando Y, Sawahata H, Kawano T, Koida K, <strong><u>Numano R<\/u><\/strong><br>J Biomed Opt,3(2),p1-4. , 2018<\/li>\n\n\n\n<li>Long nanoneedle-electrode devices for extracellular and intracellular recording in vivo.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<br>Kubota Y, Yamagiwa S, Sawahata H, Idogawa S, Tsuruhara S, <strong><u>Numano R,<\/u><\/strong> Koida K, Ishida M, Kawano T<br>Sensors and Actuators B: Chemical, 258, p1287-1294, 2018<\/li>\n\n\n\n<li>Development of microdroplet-based electroporation system for gene transfection\u3000\u3000\u3000\u3000\u3000\u3000\u3000Ishii-Teshima M, Ushiroda F, Nagai M, <strong><u>Numano R<\/u><\/strong>, Shibata T\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000The 44th International Conference on Micro and Nano Engineering 2018 (MNE 2018)<\/li>\n\n\n\n<li>Long nanowire array for in vivo in vitro DNA injections into cells in brain tissues&nbsp;&nbsp;&nbsp;\u3000\u3000\u3000\u3000\u3000\u3000Kubota Y, <strong><u>Numano R<\/u><\/strong>, Goryu A, Sawahata H, Yamagiwa S, Matsuo M, Ishida M, Kawano T\u3000\u3000\u3000\u3000\u3000The 31th IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2018)<\/li>\n\n\n\n<li>Dissolvable material-sheathed microneedle-electrode device slid into a narrow gap of the brain\u3000Yamagiwa S, Sawahata H, <strong><u>Numano R<\/u><\/strong>, Ishida M, Koida K, Kawano T\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000The 31th IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2018)<\/li>\n\n\n\n<li>Stretchable micro-doughnuts Kirigami Bioporobe&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000Morikawa Y, Yamagiwa S, Sawahata H, <strong><u>Numano R<\/u><\/strong>, Koida K, Ishida M, Kawano T\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000The 31th IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2018)<\/li>\n\n\n\n<li>Single needle electrode\u2013topped amplifier package (STACK) for in vivo applications\u3000\u3000\u3000\u3000\u3000\u3000\u3000Kita Y, Kubo H, Sawahata H, Yamagiwa S, X.L.A. Leong, <strong><u>Numano R<\/u><\/strong>, Koida K, Ishida M, Kawano T \u3000The 31th IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2018)<\/li>\n<\/ol>\n\n\n\n<h4 class=\"wp-block-heading\">2016<\/h4>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Bone Resorption Is Regulated by Circadian Clock in Osteoblasts. <br>Takarada T, Xu C, Ochi H, Nakazato R, Yamada D, Nakamura S, Kodama A, Shimba S, Mieda M, Fukasawa K, Ozaki K, Iezaki T, Fujikawa K, Yoneda Y, <strong><u>Numano R<\/u><\/strong>, Hida A, Tei H, Takeda S, Hinoi EJ,<br>Journal Of Bone And Mineral Research,32, p872-881, 2017<\/li>\n\n\n\n<li>The intrinsic microglial clock system regulates interleukin-6 expression.<br>Nakazato R, Hotta S, Yamada D, Kou M, Nakamura S, Takahata Y, Tei H, <strong><u>Numano R<\/u><\/strong>, Hida A, Shimba S, Mieda M, Hinoi E, Yoneda Y, Takarada T.<br>Glia 2017,65(1):198-208<\/li>\n\n\n\n<li>Ultra high-aspect-ratio neuroprobe: 5-\u03bcm-diameter and 400-\u03bcm-length needle detects action potentials in VIVO\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000Yamagiwa S, Sawahata H, Oi H, <strong><u>Numano R<\/u><\/strong>, Ishida M, Koida K, Kawano T\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000IEEE 30th International Conference on Micro Electro Mechanical Systems (MEMS)\u3000,p553 &#8211; 556 &nbsp;<\/li>\n\n\n\n<li>In vivo neuronal recordings using three-dimensional microneedle-electrode assembled on flexible substrate&nbsp;\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000Yamagiwa S, Sawahata H, <strong><u>Numano R<\/u><\/strong>, Ishida M, Koida K, Kawano T\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000IEEE 30th International Conference on Micro Electro Mechanical Systems (MEMS) ,p1722 &#8211; 1725<\/li>\n\n\n\n<li>In&nbsp; transfection methodology for mammalian cells using water-in-oil droplet deformation in a DC electric field\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000Kurita H, Kishikawa K, Takao Y, <strong><u>Numano R<\/u><\/strong>, Takashima K, Mizuno A\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000The 2nd World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine, and Food &amp; Environmental Technologies<\/li>\n<\/ol>\n\n\n\n<h4 class=\"wp-block-heading\">2016<\/h4>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Fundamental study on agenetransfection methodology for mammalian cellsusingwater-in-oildropletdeformationinaDC electric field<br>Kurita H, Takao;Y,, Kishikawa K, Takashima K, <strong><span style=\"text-decoration: underline;\">Numano R<\/span><\/strong>, Mizuno A.<br>Biochemistry andBiophysicsReports,\u67fb\u8aad\u6709,2016,8,p81\u201388<\/li>\n\n\n\n<li>In vivo bioluminescence and reflectance imaging of multiple organs in bioluminescence reporter mice by bundled-fiber-coupled microscopy,<br>Ando Y, Sakurai T, Koida K, Tei H, Hida A, Nakao K, Natsume M, <strong><span style=\"text-decoration: underline;\">Numano R<\/span><\/strong><br>Biomed.Opt.Express,\u67fb\u8aad\u6709,2016,7(3),p963-978<\/li>\n\n\n\n<li>Reflectance Imaging by Fiber Bundle Endoscope: Vertical Reconstruction by Multipositional Illumination<br>Ando Y, Koida K, Sawahata H, Sakurai T, Natsume M, Kawano T, and <strong><span style=\"text-decoration: underline;\">Numano R<\/span><\/strong>,<br> AIP proceedings,\u67fb\u8aad\u6709,2016<\/li>\n\n\n\n<li>Nanoscale-Tipped High-Aspect-Ratio Vertical Microneedle Electrodes for Intracellular Recordings<br>Kubota Y, Oi H, Sawahata H, Goryu A, Ando Y, <strong><span style=\"text-decoration: underline;\">Numano R<\/span><\/strong>, Ishida M, Kawano T..<br>Small,\u67fb\u8aad\u6709,2016,12(21):2846-53<\/li>\n\n\n\n<li>Intracellular Electrodes: Nanoscale-Tipped High-Aspect-Ratio Vertical Microneedle Electrodes for Intracellular Recordings<br>Kubota Y,Oi H, Sawahata H,\u3000Goryu A,Ando Y,<strong><u> Numano R<\/u><\/strong>, Ishida M, Kawano T<br>Small,12(21), p2803\u20132931, 2016<\/li>\n\n\n\n<li>Single 5\u2009\u03bcm diameter needle electrode block modules for unit recordings in vivo.&nbsp;&nbsp;<br>Sawahata H, Yamagiwa S, Moriya A, Dong T, Oi H, Ando Y, <strong><u>Numano R<\/u><\/strong>, Ishida M, Koida K, Kawano T.<br>Scientific Reports,2016,25;6:35806<\/li>\n\n\n\n<li>\u7d30\u80de\u3078\u306e\u907a\u4f1d\u5b50\u5c0e\u5165\u306e\u9769\u65b0\u7684\u65b0\u6cd5<br>\u300c\u6b21\u4e16\u4ee3\u578b\u6db2\u6ef4\u30a8\u30ec\u30af\u30c8\u30ed\u30dd\u30ec\u30fc\u30b7\u30e7\u30f3\u300d\u306e\u958b\u767a<br>&#8211; iPS\u7d30\u80de\u306e\u5927\u91cf\u88fd\u9020\u306a\u3069\u533b\u7642\u5fdc\u7528\u306b\u3080\u3051\u305f\u3082\u306e\u3064\u304f\u308a\u6280\u8853 &#8211;<br><strong><u>\u6cbc\u91ce\u3000\u5229\u4f73<\/u><\/strong><br> \u30af\u30ea\u30fc\u30f3\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u3001\u65e5\u672c\u5de5\u696d\u51fa\u7248 201\uff16\u5e74\uff11\uff11\u6708\u53f7\u3000<\/li>\n<\/ol>\n\n\n\n<h4 class=\"wp-block-heading\">2015<\/h4>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Novel parallelized electroporation by electrostatic manipulation of a water-in-oil droplet as a microreactor, e0144254 (15pp), 2015<br>Kurita H, Takahashi S, Asada A, Matsuo M, Kishikawa K, Mizuno A, <strong><span style=\"text-decoration: underline;\">Numano R<\/span><\/strong><br>PLoS One,\u67fb\u8aad\u6709,2015,10(12)<\/li>\n\n\n\n<li>Dissolvable Base Scaffolds Allow Tissue Penetration of High-Aspect-Ratio Flexible Microneedles<br>Yagi S, Yamagiwa S, Kubota Y, Sawahata H, <strong><span style=\"text-decoration: underline;\">Numano R<\/span><\/strong>, Imashioya T, Oi H, Ishida M, Kawano T.<br>Adv Healthc Mater. ,\u67fb\u8aad\u6709,2015,in press<\/li>\n\n\n\n<li>Low glucose-induced ghrelin secretion is mediated by ATP-sensitive potassium channe<br>Manami Oya1, Tetsuya Kitaguchi2,3, Kazuki Harada1, <strong><span style=\"text-decoration: underline;\">Rika Numano<\/span><\/strong>4,<br>Takahiro Sato5, Masayasu Kojima5, Takashi Tsubo<br>Journal of Endocrinology,\u67fb\u8aad\u6709,2015,226(25-34).<\/li>\n\n\n\n<li>Layer-by-layer assembled nanorough iridium-oxide\/platinum-black for low-voltage microscale electrode neurostimulation<br>Shota Yamagiwaa, Akifumi Fujishiroa, Hirohito Sawahataa, <strong><span style=\"text-decoration: underline;\">Rika Numano<\/span><\/strong>b,c,Makoto Ishidaa,b, Takeshi Kawanoa,<sup>\u2217<\/sup><br>Sensors and Actuators B: Chemical ,\u67fb\u8aad\u6709,2015,206(205\u2013211)<\/li>\n<\/ol>\n\n\n\n<h4 class=\"wp-block-heading\">2014<\/h4>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Short hairpin RNAs of designed sequences can be extracellularly produced by the marine bacterium Rhodovulum sulfidophilum<br>Nagao N, Suzuki H, <strong><span style=\"text-decoration: underline;\">Numano R<\/span><\/strong>, Umekage S, Kikuchi Y<br>J Gen Appl Microbiol. ,\u67fb\u8aad\u6709,2014,60\u5dfb\uff08222\uff5e 226\u9801\uff09<\/li>\n\n\n\n<li>Melanopsin resets circadian rhythms in cells by inducing clock genePeriod<br>Shuhei Yamashita, Tomoe Uehara, Minako Matsuo, Yo Kikuchi and <strong><span style=\"text-decoration: underline;\">Rika Numano<\/span><\/strong><br>AIP Conf. Proc. ,\u67fb\u8aad\u6709,2014,1585, 40-44<\/li>\n\n\n\n<li>A vertically integrated nanoscale tipped microprobe intracellular electrode arra<br>Kubota, Y. ,Oi, H. , Sawahata, H. , Goryu, A., Ando, Y., <strong><span style=\"text-decoration: underline;\">Numano R<\/span><\/strong>, Ishida, M. , Kawano, <br>Micro Electro Mechanical Systems (MEMS) ,\u67fb\u8aad\u6709,2014,155 \u2013 158<\/li>\n<\/ol>\n\n\n\n<h4 class=\"wp-block-heading\">2013<\/h4>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Vesicular nucleotide transporter is involved in ATP storage of secretory lysosomes in astrocyte<br>Oya M, Kitaguchib T, Yanagihara Y, <strong><span style=\"text-decoration: underline;\">Numano R<\/span><\/strong>, Kakeyama M, Ikematsu K, Tsuboi<br>Biochem Biophys Res Commun ,\u67fb\u8aad\u6709,2013,16\u5dfb(145\uff5e151\u9801\uff09<\/li>\n<\/ol>\n\n\n\n<h4 class=\"wp-block-heading\">2012<\/h4>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Small GTPase Cdc42 modulates the number of exocytosis-competent dense-core vesicles in PC12 cells.<br>Sato M, Kitaguchi T, <strong><span style=\"text-decoration: underline;\">Numano R<\/span><\/strong>, Ikematsu K, Kakeyama M, Murata M, Sato K, Tsuboi T<br>Biochem Biophys Res Commun ,\u67fb\u8aad\u6709,2012,30\u5dfb(254-269\u9801\uff09<\/li>\n\n\n\n<li>Nanoscale tipped microwire arrays enhance electrical trap and depth injection of nanoparticles<br>Goryu A, <strong><span style=\"text-decoration: underline;\">Numano R<\/span><\/strong>, Ikedo A, Ishida M, Kawano T<br>Nanotechnology. ,\u67fb\u8aad\u6709,2012,23\u5dfb\uff082741\uff5e 2705\u9801\uff09<\/li>\n\n\n\n<li>A fluorescence spotlight on the clockwork development and metabolism of bone<br>Tadahiro Iimura* , Ayako Nakane, Mayu Sugiyama, Hiroki Sato, Yuji Makino, Takashi Watanabe, Yuzo Takagi, <strong><span style=\"text-decoration: underline;\">Rika Numano<\/span><\/strong>*, Akira Yamaguchi<br>J Bone Miner Metab ,\u67fb\u8aad\u6709,2012,24\u5dfb\uff0855\uff5e 63\u9801\uff09<\/li>\n<\/ol>\n\n\n\n<h4 class=\"wp-block-heading\">2011<\/h4>\n\n\n\n<ol class=\"wp-block-list\">\n<li> \u9aa8\u306e\u6210\u9577\u3068\u4ee3\u8b1d\u306b\u304a\u3051\u308b\u6982\u65e5\u30ea\u30ba\u30e0\u306e\u50cd\u304d \uff0d\u86cd\u5149\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306b\u3088\u308b\u30a2\u30d7\u30ed\u30fc\u30c1\u3068\u5c55\u671b\uff0d<br>Ayako Nakane, <strong><span style=\"text-decoration: underline;\">Rika Numano<\/span><\/strong>* ,Yuzo Takagi , Akira Yamaguchi, Tadahiro Iimura<br>Jounal of Bone morphometry,\u67fb\u8aad\u6709,2011,21\u5dfb\uff0841-50\u9801\uff09<\/li>\n\n\n\n<li>\u53cc\u65b9\u5411\u306e\u5149\u53cd\u5fdc\u6027\u3092\u6301\u3064Yin\/Yang\u53d7\u5bb9\u4f53<br>\u7d30\u80de\u5de5\u5b66\u3001\u7f8a\u571f\u793e 2011\u5e748\u6708\u53f7\u3000\u5e73\u621023\u5e74<br><strong><u>\u6cbc\u91ce\u3000\u5229\u4f73<\/u><\/strong><\/li>\n\n\n\n<li>Fluorescent imaging approach and perspective for the circadian development and metabolism of bone<br>Jounal of Bone morphometry. Vol.21, p41-50, 2011<br>Nakane A, <strong><u>Numano R*<\/u><\/strong>, Takagi Y, Yamaguchi A, Iimura T<\/li>\n<\/ol>\n\n\n\n<h4 class=\"wp-block-heading\">2009<\/h4>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Nanosculpting reversed wavelength sensitivity into a photoswitchable iGluR.<br><strong><span style=\"text-decoration: underline;\">Numano R<\/span><\/strong>, Szobota S, Lau AY, Gorostiza P, Volgraf M, Roux B, Trauner D, Isacoff EY<br>Proc Natl Acad Sci U S A, \u67fb\u8aad\u6709,106, 2009,p6814-6819<\/li>\n\n\n\n<li>Ontogeny of circadian organization in the rat.<br>Yamazaki S, Yoshikawa T, Biscoe EW, <strong><span style=\"text-decoration: underline;\">Numano R<\/span><\/strong>, Gallaspy LM, Soulsby S, Papadimas E, Pezuk P, Doyle SE, Tei H, Sakaki Y, Block GD, Menaker M<sup>\uff0a<\/sup>.<br>J Biol Rhythms., \u67fb\u8aad\u6709, 24, 2009,\u3000p55-63<\/li>\n<\/ol>\n\n\n\n<h4 class=\"wp-block-heading\">2007<\/h4>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Remote control of neuronal activity with a light-gated glutamate receptor.<br>Szobota S, Gorostiza P, Del Bene F, Wyart C, Fortin DL, Kolstad KD, Tulyathan O, Volgraf M, <strong><span style=\"text-decoration: underline;\">Numano R<\/span><\/strong>, Aaron HL, Scott EK, Kramer RH, Flannery J, Baier H, Trauner D, Isacoff EY.<br>Neuron, \u67fb\u8aad\u6709, 54, 2007, p535-545<\/li>\n\n\n\n<li>Mechanisms of photoswitch conjugation and light activation of an ionotropic glutamate receptor.<br>Gorostiza P, Volgraf M, <strong><span style=\"text-decoration: underline;\">Numano R<\/span><\/strong>, Szobota S, Trauner D, Isacoff EY.<br>Proc Natl Acad Sci U S A, \u67fb\u8aad\u6709, 104, 2007,p10865-10870<\/li>\n\n\n\n<li>Remote control of neuronal activity with a light-gated glutamate receptor.<br>Szobota S, Gorostiza P, Del Bene F, Wyart C, Fortin DL, Kolstad KD, Tulyathan O, Volgraf M, <strong><span style=\"text-decoration: underline;\">Numano R<\/span><\/strong>, Aaron HL, Scott EK, Kramer RH, Flannery J, Baier H, Trauner D, Isacoff EY\uff0a.<br>Neuron, \u67fb\u8aad\u6709, 54, 2007, p535-545<\/li>\n<\/ol>\n\n\n\n<h4 class=\"wp-block-heading\">2006<\/h4>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Constitutive expression of the Period1 gene impairs behavioral and molecular circadian rhythms.<br><strong><span style=\"text-decoration: underline;\">Numano R<\/span><\/strong>, Yamazaki S, Umeda N, Samura T, Sujino M, Takahashi R, Ueda M, Mori A, Yamada K, Sakaki Y, Inouye ST, Menaker M, Tei H.<br>Proc Natl Acad Sci U S A, \u67fb\u8aad\u6709, 103,p3716-3721, 2006<\/li>\n\n\n\n<li>Allosteric control of an ionotropic glutamate receptor with an optical switch.<br>Volgraf M, Gorostiza P, <strong><span style=\"text-decoration: underline;\">Numano R<\/span><\/strong>, Kramer RH, Isacoff EY, Trauner D.<br>Nat Chem Biol., \u67fb\u8aad\u6709, 2, p47-52, 2006<\/li>\n<\/ol>\n\n\n\n<h4 class=\"wp-block-heading\">2004<\/h4>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Temporal precision in the mammalian circadian system: a reliable clock from less reliable neurons.<br>Herzog ED, Aton SJ, <strong><span style=\"text-decoration: underline;\">Numano R<\/span><\/strong>, Sakaki Y, Tei H.<br>J Biol Rhythms., \u67fb\u8aad\u6709,19,p35-46, 2004<\/li>\n<\/ol>\n\n\n\n<h4 class=\"wp-block-heading\">2002<\/h4>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Transgenic rats in study of mammalian circadian rhythms.<br><strong><span style=\"text-decoration: underline;\">Numano R<\/span><\/strong><br>Anitex, 14, p203-209, 2002<\/li>\n<\/ol>\n\n\n\n<h4 class=\"wp-block-heading\">2001<\/h4>\n\n\n\n<ol class=\"wp-block-list\">\n<li>The coupling of central and peripheral circadian oscillators in the mammalian circadian system by means of Period1 expression profile<br><strong><span style=\"text-decoration: underline;\">Numano R<\/span><\/strong>, Tei H<br>Shinkei Kenkyu no Shinpo, 45, p734-743, 2001<\/li>\n\n\n\n<li>The coupling of central and peripheral circadian oscillators in the mammalian circadian system by means of Period1 expression profile<br>Shinkei Kenkyu no Shinpo, 45\u5dfb\uff08734\u9801\uff5e743\u9801\uff09\u5e73\u621013\u5e74<br><strong>\u6cbc\u91ce\u3000\u5229\u4f73<\/strong>\u3001\u3000\u7a0b\u3000\u8087&nbsp;<\/li>\n<\/ol>\n\n\n\n<h4 class=\"wp-block-heading\">2000<\/h4>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Resetting central and peripheral circadian oscillators in transgenic rats.<br>*Yamazaki S, *<strong><span style=\"text-decoration: underline;\">Numano R<\/span><\/strong>, *Abe M, Hida A, Takahashi R, Ueda M, Block GD, Sakaki Y, Menaker M, Tei H.<br>Science, \u67fb\u8aad\u6709,288,p682-685, 2000\u3000\u3000*equally contributed<\/li>\n<\/ol>\n\n\n\n<h4 class=\"wp-block-heading\">1998<\/h4>\n\n\n\n<ol class=\"wp-block-list\">\n<li>2,2&#8242;-Azobis (4-methoxy-2,4-dimethylvaleronitrile), a new lipid-soluble azo initiator: application to oxidations of lipids and low-density lipoprotein in solution and in aqueous dispersions.<br>Noguchi N, Yamashita H, Gotoh N, Yamamoto Y, <strong><span style=\"text-decoration: underline;\">Numano R<\/span><\/strong>, Niki E.<br>Free Radic Biol Med., \u67fb\u8aad\u6709, 24, p259-268, 1998<\/li>\n\n\n\n<li>Oxidation of lipids in low density lipoprotein particles.<br>Noguchi N, <strong><span style=\"text-decoration: underline;\">Numano R<\/span><\/strong>, Kaneda H, Niki E.<br>Free Radic Res., \u67fb\u8aad\u6709, 29, p43-52, 1998<\/li>\n\n\n\n<li>Identification of the mammalian homologues of the Drosophila timeless gene, Timeless1.<br>Koike N, Hida A, <strong><span style=\"text-decoration: underline;\">Numano R<\/span><\/strong>, Hirose M, Sakaki Y, Tei H.<br>FEBS Lett., \u67fb\u8aad\u6709, 441,p427-431, 1998<\/li>\n\n\n\n<li>Human clock controlled gene, Period1<br><strong><span style=\"text-decoration: underline;\">Numano R<\/span><\/strong> , Tei H , Sakaki Y<br>Medical Technology, 26, p213-215, 1998<\/li>\n\n\n\n<li>Human clock controlled gene, Period1<br>Medical Technology, 26\u5dfb\uff08213\u9801\uff5e215\u9801\uff09\u5e73\u621010\u5e74<br>\u533b\u6b6f\u85ac\u51fa\u7248\u682a\u5f0f\u4f1a\u793e<br><strong><u>\u6cbc\u91ce\u3000\u5229\u4f73<\/u><\/strong>\u3001\u3000\u7a0b\u3000\u8087\u3001\u698a\u3000\u4f73\u4e4b<\/li>\n<\/ol>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"2\">\u51fa\u7248\u56f3\u66f8<\/h3>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Fluorescent imaging approach and perspective for the circadian development and metabolism of bone<br>Nakane A,<strong><u> Numano R*<\/u><\/strong> , Takagi Y, Yamaguchi A, Iimura T* * to whom correspondence should be addressed<br>\u9aa8\u5f62\u614b\u8a08\u6e2c\u5b66\u4f1a\u96d1\u8a8c, \u67fb\u8aad\u670921, 2011, 41-50<\/li>\n\n\n\n<li>A fluorescence spotlight on the clockwork development and metabolism of bone<br>Nakane A, <strong><u>Numano R*<\/u><\/strong>, Sugiyama M, Sato H, Makino Y, Watanabe T, Takagi Y, Yamaguchi A, Iimura T<sup>*<\/sup>\u3000* to whom correspondence should be addressed<br>J Bone Miner Metab, \u67fb\u8aad\u6709,in print<\/li>\n\n\n\n<li>\u7d30\u80de\u5de5\u5b66\u3000<strong><span style=\"text-decoration: underline;\">Numano R<\/span><\/strong><br>\u53cc\u65b9\u5411\u306e\u5149\u53cd\u5fdc\u6027\u3092\u3082\u3064Yin\/Yang\u53d7\u5bb9\u4f53<br>2011\u5e74\u3001\u7f8a\u571f\u793e<\/li>\n<\/ol>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"3\">\u7814\u7a76\u52a9\u6210<\/h3>\n\n\n\n<ol class=\"wp-block-list\">\n<li>\u3010\u79d1\u5b66\u7814\u7a76\u8cbb\u88dc\u52a9\u91d1\u3000\u82e5\u624b\u7814\u7a76\uff08B\uff09\u7814\u7a76\u4ee3\u8868\u8005\uff08H21\uff5eH23\uff09\u3011<br>\u300e\u6982\u65e5\u30ea\u30ba\u30e0\u304c\u78ba\u7acb\u3059\u308b\u6642\u671f\u306b\u3064\u3044\u3066\u306e\u7814\u7a76\u300f<br>SCN\u306b\u304a\u3044\u3066\u3001\u7d0424\u6642\u9593\u306e\u81ea\u5f8b\u7684\u306a\u5468\u671f\u30ea\u30ba\u30e0\u306e\u767a\u632f\u304c\u767a\u751f\u6bb5\u968e\u306e\u3044\u3064\u78ba\u7acb\u3059\u308b\u304b\u3092\u3001SCN\u30b9\u30e9\u30a4\u30b9\u57f9\u990a\u3084\u5404\u7d44\u7e54\u306e\u9855\u5fae\u93e1\u89b3\u5bdf\u3067\u3001\u795e\u7d4c\u7d30\u80de\u306e\u5206\u88c2\u3059\u308b\u69d8\u5b50\u3092\u540c\u6642\u306b\u307f\u306a\u304c\u3089\u660e\u3089\u304b\u306b\u3059\u308b\u3002\u307e\u305f\u3001\u74b0\u5883\u5909\u5316\u306a\u3069\u306e\u5916\u754c\u306e\u523a\u6fc0\u3067\u3001\u80ce\u5150\u3084\u4e73\u5150\u306e\u6982\u65e5\u30ea\u30ba\u30e0\u306e\u78ba\u7acb\u3059\u308b\u6642\u671f\u3084\u4f4d\u76f8\u5909\u5316\u306e\u6a5f\u80fd\u304c\u3001\u3069\u306e\u3088\u3046\u306a\u5f71\u97ff\u3092\u53d7\u3051\u308b\u304b\u3092\u540c\u69d8\u306e\u624b\u6cd5\u3067\u8abf\u3079\u308b\u3002\u624b\u6cd5\u3068\u3057\u3066\u306f\u3001\u7d30\u80de\u5468\u671f\u306eS-G2-M\u671f\u3084G1\u671f\u306e\u30bf\u30a4\u30df\u30f3\u30b0\u304c\u3001\u7dd1\u8272\u86cd\u5149\u3068\u8d64\u8272\u767a\u5149\u3067\u89b3\u5bdf\u3067\u304d\u308b\u7d44\u307f\u63db\u3048\u30de\u30a6\u30b9\u3068\u3001\u6982\u65e5\u30ea\u30ba\u30e0\u306e\u9032\u884c\u304c\u7dd1\u86cd\u5149\u3001\u9ec4\u8272\u767a\u5149\u30ea\u30dd\u30fc\u30bf\u30fc\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3067\u308f\u304b\u308b\u7d44\u307f\u63db\u3048\u30de\u30a6\u30b9\u3092\u304b\u3051\u3042\u308f\u305b\u308b\u3002\u3053\u306edouble\u7d44\u307f\u63db\u3048\u30de\u30a6\u30b9\u306eSCN\u30b9\u30e9\u30a4\u30b9\u3084\u5404\u7d44\u7e54\u3092\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3057\u3001\u7d30\u80de\u5468\u671f\u3068\u6982\u65e5\u30ea\u30ba\u30e0\u306e\u9032\u884c\u3092\u86cd\u5149\u30fb\u767a\u5149\u91cf\u306e\u6642\u9593\u5909\u5316\u3067\u89b3\u5bdf\u3059\u308b\u3002\u7d44\u307f\u63db\u3048\u30de\u30a6\u30b9\u306e\u767a\u751f\u6bb5\u968e\u3092\u304a\u3063\u3066\u3001\u80ce\u5150\u3001\u65b0\u751f\u5150\u3001\u4e73\u5150\u3001\u751f\u4f53\u306e\u7d30\u80de\u5468\u671f\u3068\u6982\u65e5\u30ea\u30ba\u30e0\u3092\u89b3\u5bdf\u3059\u308b\u3002<br>\u3053\u306e\u7814\u7a76\u3067\u5f97\u3089\u308c\u308b\u3001\u69d8\u3005\u306a\u74b0\u5883\u4e0b\u3067\u81ea\u5f8b\u7684\u306a\u5468\u671f\u30ea\u30ba\u30e0\u306e\u767a\u632f\u304c\u3001\u767a\u751f\u6bb5\u968e\u306e\u3044\u3064\u78ba\u7acb\u3059\u308b\u304b\u3068\u3044\u3046\u77e5\u898b\u306f\u3001\u767a\u751f\u521d\u671f\u306e\u3044\u3064\u3054\u308d\u306b\u795e\u7d4c\u7d30\u80de\u306e\u767a\u706b\u306e\u523a\u6fc0\u3092\u4e0e\u3048\u308c\u3070\u3088\u3044\u304b\u3068\u3044\u3046\u60c5\u5831\u3092\u63d0\u4f9b\u3059\u308b\u305f\u3081\u306b\u3001\u524d\u8ff0\u306e\u8abf\u6574\u8cbb\u3092\u7528\u3044\u3066\u884c\u3046\u7814\u7a76\u6d3b\u52d5\u306b\u5f79\u7acb\u3064\u3002 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